Endocrine-Metabolic Interplay in MASLD

MASLD represents far more than a liver disease. It is a systemic metabolic disorder driven by a complex interplay between the liver and multiple endocrine pathways, including insulin, thyroid hormones, growth hormone, and sex hormones. Understanding this endocrine-metabolic crosstalk is crucial because MASLD sits at the intersection of obesity, type 2 diabetes, cardiovascular disease, and metabolic syndrome. As emerging therapies increasingly target these hormonal pathways, an integrated endocrine and metabolic approach is becoming essential to improve patient outcomes and reshape the future of MASLD management.